Aromatase inhibitors, mechanism of actions, uses, side effects & dosage

Uncommon, but potentially severe side effects ofLetrozole include decrease in bone mineral density, increases in serum cholesterol levels and embryo-fetal toxicity 25. Common anastrozole side effects include hot flashes, night sweats, fatigue, dizziness, headache, somnolence, abdominal discomfort, nausea, arthralgias, weight gain and rash 23. Uncommon, but potentially severe side effects of anastrozole include decrease in bone mineral density, increase in serum cholesterol and increased rate of cardiovascular events.

Other ways to naturally block estrogen

Estrogen stimulates the synthesis of prostaglandin E2 (PGE2), which causes increased aromatase activity in the endometrium. This vicious cycle leads to the growth of ectopic endometrial tissue, which is blocked by aromatase inhibitors by inhibiting the synthesis of estrogen in extrauterine endometrial tissue 14, 15. The most common side effects of aromatase inhibitors are symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. This side effect can be serious enough to cause some women to stop taking the drugs. Aromatase inhibitors are a class of drug used to prevent cancer recurrence in postmenopausal women with estrogen receptor-positive breast cancer.

No dose adjustment is necessary for patients with renal or liver impairment or elderly patients. Anastrozole (Arimidex), a selective aromatase inhibitor, is available as a 1 mg tablet, which is to be taken orally once a day, with or without food. No dose adjustment is necessary for patients with kidney or liver impairment or elderly patients.

The production of testosterone reduces, the conversion to estrogen increases, and we get more severe symptoms every time. Thus, if you are starting to have symptoms of low testosterone, it will be useful to check your levels of estradiol as well. Estrogen dominance is sometimes detected with low testosterone symptoms. According to studies, higher levels of estrogen cause a thickening of the carotid artery. Patients with low testosterone and high estrogen levels tend to feel tired more easily. Circulating levels transform into estrogen, and males start displaying low sexual drive.

Levels of Evidence

• A 2015 study in the New England Journal of Medicine reported that the use of Aromasin in women on ovary suppression therapy was just as effective in preventing recurrence after five years as tamoxifen.
• As you have seen, there’s not a single factor behind estrogen dominance.
• We use established science and your goals to develop a treatment program.
• Moreover, aromatase inhibitors can be used in premenopausal women if they are given together with a drug that suppresses ovarian function.

In three small winstrol 50 mg bodybuilding studies, letrozole or testolactone has been administered to morbidly obese men to improve their testosterone levels [42-44]. Aromatase inhibitors are widely prescribed for hormone-responsive breast carcinoma in postmenopausal women. It is well known that aromatase inhibition results in a dramatic reduction of tumor estrogen concentrations [66]. As gynecomastia in men presumably results from an imbalance between androgen and estrogen action, aromatase inhibition was tested as a treatment for gynecomastia in boys. Treatment with anastrozole daily for 6 months, however, did not result in a significant improvement compared with placebo [67]. This is in accordance with the data summarized in a recent review [68], describing similar responses to placebo, tamoxifen and anastrozole in a number of observational studies.

As part of the steroidogenesis pathway, testosterone is metabolized into either dihydrotestosterone (DHT) by the 5-alpha reductase enzyme or estradiol by the aromatase enzyme. They have been very effective in treating breast cancer in women, but they have not been well-studied in men. Still, some doctors use them to treat advanced breast cancer in men, often combined with a luteinizing hormone-releasing hormone (LHRH) analog to turn off hormone production by the testicles (discussed below). These drugs are known as selective estrogen receptor modulators (SERMs).

Why Choose Ben’s Natural Health Supplements?

To understand why aromatase inhibitors for men are beneficial, it’s crucial to understand more about estrogen in male physiology. Estrogen plays a vital role in bone and vascular health in men and is believed to play some part in the actual function of sex – libido, erections, etc. – and weight loss. For this reason, it is not advised to inhibit all estrogen production. The aim of Testosterone Replacement Therapy should be to balance both testosterone and estrogen levels in the male body appropriately. Letrozole (Femara) is in a class of medications called aromatase inhibitors.

They may be used to increase gonadotropin secretion and thereby stimulate Leydig and Sertoli cell function. Aromatase inhibitors may be used to prevent or delay epiphysial closure and thereby increase adult height. A major concern of aromatase inhibition is the possible detrimental effect on bone mineralization. These places offer services at “rock-bottom” rates and prey on other men’s misinformation about how hormones work – especially estrogen.